Currently the only way to update wedge address configs is through creating a support ticket. This does change the values at runtime.
For testing, you can change the values in your dev environment either by stopping the server, and changing a value and then restarting it. You should be able to do that at any point and it should create the same effect as long as you aren't restarting the server in the middle of a call.
How often are you planning on needing to update the wedge address configs?